High expression locus vector based on ferritin heavy chain gene locus
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United States of America Patent
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Issued Date -
Feb 8, 2007
app pub date -
Oct 22, 2003
filing date -
Oct 24, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
High expression locus vectors based, in part, on the ferritin heavy chain locus are disclosed. The vectors include distal 5' flanking sequences and/or proximal 5' regulatory sequences derived from ferritin heavy chain locus. The vectors include a site for insertion of heterologous sequences and proximal 3' regulatory and distal 3+ flanking sequences. The proximal 3' regulatory and distal 3' flanking sequences are optionally derived from the ferritin heavy chain locus. Cells transformed with the vectors, and methods of producing heterologous proteins encoded by the vectors, are also disclosed.
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