Oligonucleotide compound and method for treating nidovirus infections
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United States of America Patent
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Issued Date -
Feb 15, 2007
app pub date -
May 10, 2006
filing date -
Dec 24, 2003
priority date (Note) -
Abandoned
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Abstract
A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5' leader region of the positive-strand viral genome and negative-strand 3' subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.
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