Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
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United States of America Patent
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Issued Date -
Feb 15, 2007
app pub date -
May 11, 2006
filing date -
Oct 23, 2003
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Abandoned
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Abstract
The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of human immunodeficiency virus-1 (HOV-1), as in treatment of a viral infection. The antisense antiviral compounds have morpholino subunits linked by uncharged phosphorodiamidate linkages interspersed with cationic phosphorodiamidate linkages. An exemplary embodiment of the invention provides an antisense compound directed to the HIV Vif gene, causing the production of defective HIV- 1 virions in an infected individual.
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