Nanoparticulate probe for in vivo monitoring of tissue oxygenation
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United States of America Patent
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Nov 29, 2011
Grant Date -
Feb 22, 2007
app pub date -
Mar 1, 2006
filing date -
Sep 5, 2003
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Abstract
A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
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