Nucleic acid vaccine compositions having a mammalian CD80/CD86 gene promoter driving antigen expression

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United States of America Patent

SERIAL NO

11505326

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Abstract

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Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.

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Patent Owner(s)

Patent OwnerAddress
POWDERJECT RESEARCH LIMITEDNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Umlauf, Scott Madison, WI 8 68

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