Cross-linked polysacharide and protein matrices and methods for their preparation
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United States of America Patent
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Issued Date -
Mar 8, 2007
app pub date -
Aug 31, 2006
filing date -
Sep 2, 2005
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Abandoned
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Abstract
Methods for preparing cross-linked polysaccharide matrices by cross-linking one or more amino group containing polysaccharides or amino-functionalized polysaccharides with reducing sugars and/or reducing sugar derivatives. The resulting matrices may include polysaccharide matrices and composite cross-linked matrices including polysaccharides cross-linked with proteins and/or polypeptides. Additives and/or cells may also be included in or embedded within the matrices. Various different solvent systems and reducing sugar cross-linkers for performing the cross-linking are described. The resulting matrices exhibit various different physical, chemical and biological properties.
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