Mucosal immunization to prevent prion infection

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United States of America Patent

PATENT NO 8685718
APP PUB NO 20070059807A1
SERIAL NO

10558276

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Abstract

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Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration. Suitable adjuvants include cholera toxin subunit B, heat-labile enterotoxin and aluminum hydroxide. Alternatively, the vaccine comprises a vector encoding a prion protein, fragment, or homolog in an attenuated Salmonella host. The vaccines can be used to prevent or treat prion disease in humans and other mammals.

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Patent Owner(s)

  • NEW YORK UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chabalgoity, Jose Alejandro Montevidco Cp, UY 4 8
Frangione, Blas New York, US 17 426
Goni, Fernando R Montevideo Cp, UY 3 26
Sigurdsson, Einar M New York, US 25 442
Wisniewski, Thomas Staten Island, US 29 411

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