Method for quantitatively determining the LDL particle number in a distribution of LDL cholesterol subfractions
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United States of America Patent
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Issued Date -
Mar 29, 2007
app pub date -
Sep 18, 2006
filing date -
Sep 29, 2005
priority date (Note) -
Abandoned
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Abstract
The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a LDL subfraction. The method features the steps of: 1) measuring an initial distribution of LDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of LDL particles with a mathematical model to determine a modified distribution of LDL particles (e.g., a relative particle distribution); 3) determining a total LDL particle number value from a blood sample; and 4) analyzing both the modified distribution of particles and the total LDL particle number value to calculate the particle number value in an LDL subfraction.
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