Heterocyclic aspartyl protease inhibitors
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United States of America Patent
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Sep 22, 2009
Grant Date -
Mar 29, 2007
app pub date -
Dec 13, 2004
filing date -
Dec 15, 2003
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Abstract
Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
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