Antigen binding molecules having modified Fc regions and altered binding to Fc receptors
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United States of America Patent
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Issued Date -
May 17, 2007
app pub date -
May 9, 2006
filing date -
May 9, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and vectors encoding such antigen binding molecules, to host cells comprising the same, to methods for making the antigen binding molecules of the invention, and to their use in the treatment of various diseases and disorders, e.g., cancers.
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