Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
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United States of America Patent
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Jan 27, 2009
Grant Date -
May 24, 2007
app pub date -
Oct 13, 2006
filing date -
Oct 14, 2005
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A new process is described for obtaining 5-cyanophthalide, which is an intermediate used for the synthesis of citalopram and its active enantiomer S(+) citalopram, both of which are known active ingredients commonly used for treating depression. The process involves starting from 5-carboxyphthalide which is converted into the corresponding acylochloride. The latter is reacted with hydroxylamine to produce the corresponding hydroxamyl phthalide, which is subsequently subjected to a dehydration reaction to produce 5-cyanophthalide.
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