Method for preparing modified release pharmaceutical compositions
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United States of America Patent
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N/A
Issued Date -
May 31, 2007
app pub date -
Oct 4, 2004
filing date -
Oct 3, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A method for the preparation of a pharmaceutical particulate composition for modified release of one or more therapeutically, prophylactically and/or diagnostically active substances, the method involving spraying of a composition comprising an oily material on a solid composition in order to subject the solid composition to a controlled agglomeration process, whereby individual particles are aggregated into agglomerates in a controlled manner and a relatively small particle size and particle size distribution is obtained, the particulate composition comprising a sufficient amount of at least one release-rate modifying substance to provide a modified release of the active substance sufficient to provide duration of therapeutic, prophylactic and/or diagnostic effect of at least about 2 hours when the composition is exposed to an aqueous environment.
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