Apparatus and methods for sealing a vascular puncture
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United States of America Patent
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Sep 28, 2010
Grant Date -
May 31, 2007
app pub date -
Jan 25, 2007
filing date -
Nov 5, 2004
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
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