Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix
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United States of America Patent
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Feb 14, 2012
Grant Date -
Jun 7, 2007
app pub date -
Nov 17, 2006
filing date -
Oct 14, 2004
priority date (Note) -
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Abstract
The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. In one embodiment, these materials include human recombinant platelet derived growth factor (rhPDGF-BB) and a biocompatible matrix. In another embodiment, these materials include rhPDGF-BB, a deproteinized bone block or calcium phosphate, and a bioresorbable membrane. The use of these materials in the present method is effective in regenerating maxillofacial bones and facilitating achievement of stable osseointegrated implants. The mandible and maxilla are preferred bones for augmentation, and enhancement of the alveolar ridge is a preferred embodiment of the present invention.
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