Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device

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United States of America Patent

SERIAL NO

11560356

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Abstract

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A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

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Patent Owner(s)

Patent OwnerAddress
ORBUSNEICH MEDICAL PTE LTD79 ANSON ROAD #07-03 SINGAPORE 079906

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cottone, Robert John JR Davie, FL 8 418
Kutryk, Michael John Bradley Ontario, CA 11 287
Rowland, Stephen M Miami, FL 26 2422
Yoklavich, Margaret Pearlington, MS 4 306

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