Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy
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United States of America Patent
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Jul 13, 2010
Grant Date -
Jun 21, 2007
app pub date -
Dec 19, 2005
filing date -
May 24, 2004
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Abstract
The present invention includes apparatuses and methods for mitigating the effects of foreign interferents on analyte measurements. The present invention comprises several interferent mitigation steps. Examples include sample cleaning procedures, detection of the presence of interferents, determination of the identity of interferents, and modification or selection of a multivariate calibration model to mitigate the effects of one or more interferents on analyte measurements. The interferent mitigation steps of the present invention can be applied individually, and in some embodiments can be applied in combination. Some examples of relevant analyte measurements include the noninvasive determination of the presence or concentration of alcohol, glucose, urea, byproducts of alcohol metabolism, and substances of abuse.
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