Pharmaceutical compositions and methods for metabolic modulation
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United States of America Patent
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Issued Date -
Jul 12, 2007
app pub date -
Aug 5, 2004
filing date -
Aug 8, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and dyslipidemia In still further preferred aspects, compounds with cytokinin activity are used to activate AMPK and/or Akt. Consequently, various diseases associated with dysregulation of AMPK and/or Akt may be treated using the compounds of the present inventive subject matter.
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