Propofol formulation containing reduced oil and surfactants
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United States of America Patent
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app pub date -
May 7, 2004
filing date -
May 9, 2003
priority date (Note) -
Abandoned
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Abstract
Sterile, stable pharmaceutical formulations of emulsions of neat propofol or propofol dissolved in a solvent and containing no preservative are provided that comprise optimal amounts of surfactants such as lecithin and solvent such as soybean oil, with a suitable pH range to prevent significant growth of microorganisms for at least 24 hours after adventitious, extrinsic contamination. The lower amount of oil or absence (oil) in the formulation also allows chronic sedation over extended periods of time with a reduced chance of lipid overload in the blood.
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