Morphogen compositions and methods of use thereof to treat heart disorders
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United States of America Patent
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Issued Date -
Jul 26, 2007
app pub date -
Jan 24, 2006
filing date -
Jan 24, 2006
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Abandoned
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Abstract
Disclosed are compositions and methods for preventing, treating, or reducing symptoms associated with a myocardial or related disorder such as an infarction. In one embodiment, the method includes administering a therapeutically effective amount of a nucleic acid encoding at least one morphogen; or an effective fragment thereof. Preferred morphogens include the human Sonic Hedghog (Shh), human Desert Hedgehog (Dhh), and human Indian Hedgehog (Ihh) proteins. The methods can be used alone or in combination with other methods involving administration of an angiogenic protein, hematopoietic protein, or endothelial precursor cells (EPCs).
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