Mucosal vascular addressins and uses thereof

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United States of America Patent

PATENT NO 8277808
APP PUB NO 20070178089A1
SERIAL NO

11732400

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Abstract

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The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a polypeptide with at least 90% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, said naturally occurring human MAdCAM binds α4β7, and wherein said isolated antibodies and antigen-binding fragments thereof inhibit binding of said naturally occurring human MAdCAM to human α4β7, and wherein said antibody inhibits adhesion of RPMI 8866 cells to cells that express said human MAdCAM.

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Patent Owner(s)

  • MILLENNIUM PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Briskin, Michael J Lexington, US 12 79

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