ELECTRICAL MEASUREMENT OF CELL INVASION
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United States of America Patent
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Issued Date -
Aug 9, 2007
app pub date -
Feb 2, 2007
filing date -
Feb 3, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The electrical measurement of invasive cell movement is provided. A gel layer is added to a well including a substrate having an electrode thereon. A medium is added over the gel layer. One of the medium and the gel layer can include cells and the other of the medium and the gel layer can comprise a compound to be evaluated for its influence on cell migration. An electrical signal is applied to the electrode and a property (e.g., impedance) of the electrical signal is measured. By analyzing the property, it can be determined whether and to what extent cells are in contact with the electrode. An influence of the compound on cell migration can be correlated with the property.
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