Compositions for the treatment and prevention of heart disease and methods of using same
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United States of America Patent
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Issued Date -
Sep 6, 2007
app pub date -
Oct 13, 2006
filing date -
Oct 13, 2005
priority date (Note) -
Abandoned
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Abstract
The combination of nitric oxide generating compounds which are not dependent upon aldehyde dehydrogenase for bioactivation, or are specifically targeted to nNOS or the sarcoplasmic reticulum of cardiac muscle cells, and xanthine oxidase inhibitors are effective in the treatment of heart disease, specifically congestive heart failure and ischemic coronary disease. This treatment is particularly effective in patients who have particularly heavy oxidative burdens, e.g. diabetics, patients with lung disorders, patients with sickle cell anemia and patients of Asian descent.
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