Process for preparing cyclohexanediacetic acid monoamide

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United States of America Patent

PATENT NO 7381823
APP PUB NO 20070208175A1
SERIAL NO

10599009

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Abstract

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A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.

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Patent Owner(s)

Patent OwnerAddress
SERICHIM S R L33050 TORVISCOSA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Danieli, Bruno Milan, IT 3 3
Delogu, Pietro Trieste, IT 8 2
Fugazza, Lorenza San Fiorano, IT 31 106
Rosa, Sabrina De Cervignano del Friuli, IT 1 0

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