Lipid-Mediated Polynucleotide Administration to Deliver a Biologically Active Peptide and to Induce a Cellular Immune Response

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United States of America Patent

SERIAL NO

11749509

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Abstract

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A method for delivering a naked or isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of a naked polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.

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Patent Owner(s)

Patent OwnerAddress
VICAL INCORPORATEDSAN DIEGO CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carson, Dennis A Del Mar, CA 115 5300
FELGNER, Phillip L Rancho Santa Fe, CA 5 3
Malone, Robert Wallace Chicago, IL 10 1076
Rhodes, Gary H Leucadia, CA 13 2901
Wolff, Jon Asher Madison, WI 11 1010

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