Methods of Preparation and Resolution of E/Z Isomers of Vinylfuro[2,3-D]Pyrimidine and their Biological Activities and related compositions and methods of treatment
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United States of America Patent
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Issued Date -
Sep 20, 2007
app pub date -
Mar 19, 2007
filing date -
Mar 20, 2006
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Abandoned
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Abstract
Stereoselective methods for preparing the individual isomers, E- and Z-2,4-substituted-5-vinylfuro[2,3-d]pyrimidine and pharmaceutically acceptable salts, solvates, and prodrugs thereof using selective synthetic conditions are presented. This class of pyrimidine compounds function as receptor tyrosine kinase inhibitors during angiogenesis and resists the development of new blood vessels in tumors. These compounds also inhibit the folate pathway required for cell growth. The isomers of these compounds are resolved by physical, chromatographic, and/or HPLC methods. Their biological activities are described.
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