Oxime-containing acyl guanidines as beta-secretase inhibitors
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United States of America Patent
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Jun 24, 2008
Grant Date -
Oct 4, 2007
app pub date -
Mar 29, 2007
filing date -
Apr 3, 2006
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Abstract
There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) ##STR00001## or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by .beta.-secretase and, more specifically, inhibit the production of A.beta.-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to .beta.-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
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