Processes for improved disulfide bond formation in recombinant systems
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United States of America Patent
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Issued Date -
Oct 11, 2007
app pub date -
Apr 6, 2007
filing date -
Apr 7, 2006
priority date (Note) -
Abandoned
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Abstract
Methods and prokaryotic expression systems for producing recombinant disulfide bond-containing proteins are described including increasing the level of at least one redox cofactor in the cell to enhance disulfide bond formation are disclosed. Processes of increasing levels of redox cofactors include media supplementation and genetic modification of the host cell. The process can yield increased levels of soluble or active protein, or can assist the proper processing of recombinant proteins in expression systems.
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