ENRICHMENT OF CIRCULATING FETAL DNA
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United States of America Patent
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Issued Date -
Oct 18, 2007
app pub date -
Apr 11, 2007
filing date -
Apr 12, 2006
priority date (Note) -
Abandoned
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Abstract
A non-invasive screening or diagnostic method for determining the likelihood of a fetus with a genetic abnormality or a potential pregnancy complication, which utilizes a liquid blood sample from a pregnant woman. Antibodies specific to a section of histone 3.1 which is exposed to a far greater extent in chromatin of fetal origin than in chromatin of maternal origin are used to sequester and isolate such fetal nucleosomes including the associated fetal DNA. Following isolation/enrichment of such fetal DNA, genetic analysis is carried out using known molecular diagnostics.
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