STABLE HYDROALCOHOLIC ORAL SPRAY FORMULATIONS AND METHODS
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United States of America Patent
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Issued Date -
Oct 25, 2007
app pub date -
Apr 19, 2007
filing date -
Apr 19, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Stable formulations of an active pharmaceutical agent suitable for oral spray administration for absorption by the oral mucosa and related methods of preparation and administration of active pharmaceutical agent formulations are provided. Preferred embodiments of the invention provide formulations comprising an active pharmaceutical agent, a solvent, a buffer, and a viscosity modifying agent, wherein when a unit dose volume of about 25 to 400 mcL of the oral spray composition is sprayed, the spray has a median particle size diameter of about 40 to about 100 microns.
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