Multifunctional and Multivalent Angiogenesis Inhibitors
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United States of America Patent
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Issued Date -
Nov 1, 2007
app pub date -
Oct 31, 2005
filing date -
Nov 2, 2004
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Abandoned
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Abstract
Multifunctional and multivalent angiogenesis inhibitors are made up of fusion proteins comprising a polypeptide which recognizes and blocks a functionally active region of a molecule involved in the angiogenesis process and a polypeptide comprising an oligomerization domain and functionally active, inhibitor or modulator region of the angiogenesis process, separated by a proteinase-sensitive region. These inhibitors are applicable in treating and preventing pathologies occurring with angiogenesis process, for example cancer, rheumatic arthritis or psoriasis.
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