Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)

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United States of America Patent

APP PUB NO 20070265329A1
SERIAL NO

11433917

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Abstract

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A pharmaceutical composition for the sustained release of an effective amount of a selective 5-hydroxytryptamine 3 (5-HT.sub.3) receptor antagonist for the prevention, reduction or alleviation of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a course of emetogenic chemotherapy, wherein the composition is administered by subcutaneous injection, the composition comprising a 5-HT.sub.3 receptor antagonist, a semi-solid delivery vehicle and a pharmaceutically acceptable liquid excipient; wherein the composition, when administered in a single dosage, provides a controlled release of the 5-HT.sub.3 receptor antagonist and prolonging the release of the 5-HT.sub.3 receptor antagonist that tracks the profile of the incidence of vomiting.

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Patent Owner(s)

Patent OwnerAddress
AP PHARMA INC123 SAGINAW DRIVE REDWOOD CITY CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barr, John Redwood City, CA 39 342
Baxter, Brian Redwood City, CA 20 685
Devang, Shah T Redwood City, CA 1 27
Heller, Jorge Ashland, OR 64 2385

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