US Patent Application No: 2007/0266,455

Number of patents in Portfolio can not be more than 2000

PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF

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Abstract

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Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DSM IP ASSETS B.V.6411 TE HEERLEN1085

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Metz, James G Longmont, CO 80 2523
Weaver, Craig A Boulder, CO 49 1564
Zirkle, Ross Longmont, CO 40 721

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
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UNIVERSITY OF YORK (1)
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E. I. DU PONT DE NEMOURS AND COMPANY (2)
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MARTEK BIOSCIENCES CORPORATION (2)
* 2008/0038,378 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 39 2007
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The Board of Trustees of the Leland Stanford Junior University (1)
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Biotica Technology Limited (1)
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ROCHE DIAGNOSTICS GMBH (1)
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SUPERMEDIA LLC (1)
* 2008/0044,870 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
 
MARTIN ENGINEERING COMPANY (1)
* 2008/0053,791 Bulk Material Handling System and Control 3 2007
 
Kosan Biosciences, Inc. (1)
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IACR-Rothamsted (1)
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MONSANTO COMPANY (2)
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ABBOTT LABORATORIES (2)
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DSM IP ASSETS B.V. (48)
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* 5,908,622 Food product containing thraustochytrium and/or schizochytrium microflora and an additional agricultural based ingredient 78 1997
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* 7,247,461 Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof 41 2002
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* 7,214,853 Schizochytrium PKS genes 56 2002
* 7,211,418 PUFA polyketide synthase systems and uses thereof 65 2004
* 7,217,856 PUFA polyketide synthase systems and uses thereof 64 2004
* 7,256,022 Pufa polyketide synthase systems and uses thereof 50 2005
* 7,259,295 PUFA polyketide synthase systems and uses thereof 50 2005
* 7,256,023 PUFA polyketide synthase systems and uses thereof 51 2005
* 7,271,315 PUFA polyketide synthase systems and uses thereof 63 2006
* 2007/0256,146 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 45 2007
* 2007/0244,192 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 65 2007
* 2007/0270,494 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 62 2007
* 2008/0032,296 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
* 2008/0026,436 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
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* 2008/0032,351 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0038,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
* 2008/0026,440 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0026,439 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
* 2008/0026,438 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
* 2008/0022,422 CHIMERIC PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 60 2007
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* 2008/0044,867 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0038,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
* 2008/0038,792 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
* 2008/0050,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
* 2008/0044,868 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
* 2008/0044,869 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
* 2008/0038,797 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0038,795 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0038,796 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
* 2008/0038,793 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0038,794 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
* 2008/0044,873 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0044,871 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0044,872 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0040,822 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 46 2007
* 2008/0032,367 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0032,369 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0032,368 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
* 2008/0038,799 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0038,798 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0044,874 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0032,338 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
 
Sagami Chemical Research Center (3)
* 5,246,841 Microbial process for production of eicosapentaenoic acid 69 1991
* 5,683,898 Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid 76 1995
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Bioriginal Food & Science Corp. (1)
* 7,087,432 Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof 59 2001
 
SEMBIOSYS GENETICS INC. (1)
* 2007/0245,431 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 68 2007
 
WASHINGTON STATE UNIVERSITY (1)
* 2004/0010,817 Plant acyl-CoA synthetases 49 2003
 
Miami University, an Ohio corporation (1)
* 2004/0139,498 Fatty acid elongase 3-ketoacyl CoA synthase polypeptides 48 2004
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
MARTEK BIOSCIENCES CORPORATION (1)
* 2008/0038,378 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 39 2007
 
DSM IP ASSETS B.V. (46)
8,829,274 Schizochytrium PKS genes 0 2007
* 2009/0098,622 SCHIZOCHYTRIUM PKS GENES 6 2007
7,759,548 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 5 2007
* 2007/0270,494 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 62 2007
* 2007/0244,192 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 65 2007
7,939,716 PUFA polyketide synthase systems and uses thereof 3 2007
7,906,706 PUFA polyketide synthase systems and uses thereof 3 2007
7,902,427 PUFA polyketide synthase systems and uses thereof 3 2007
7,626,009 PUFA polyketide synthase systems and uses thereof 3 2007
7,601,522 PUFA polyketide synthase systems and uses thereof 5 2007
* 2008/0026,434 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0026,437 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0026,435 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 44 2007
* 2008/0026,436 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
7,960,524 PUFA polyketide synthase systems and uses thereof 3 2007
7,842,796 PUFA polyketide synthase systems and uses thereof 3 2007
7,816,504 PUFA polyketide synthase systems and uses thereof 3 2007
7,608,703 PUFA polyketide synthase systems and uses thereof 5 2007
7,608,702 PUFA polyketide synthase systems and uses thereof 5 2007
* 2008/0038,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
* 2008/0032,351 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0026,440 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0026,438 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
8,003,772 Chimeric PUFA polyketide synthase systems and uses thereof 7 2007
7,897,844 PUFA polyketide synthase systems and uses thereof 3 2007
7,973,149 PUFA polyketide synthase systems and uses thereof 3 2007
7,919,320 PUFA polyketide synthase systems and uses thereof 3 2007
7,807,442 PUFA polyketide synthase systems and uses thereof 3 2007
7,605,245 PUFA polyketide synthase systems and uses thereof 5 2007
* 2008/0044,867 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 38 2007
* 2008/0038,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
7,897,391 PUFA polyketide synthase systems and uses thereof 3 2007
7,897,392 PUFA polyketide synthase systems and uses thereof 3 2007
7,897,393 PUFA polyketide synthase systems and uses thereof 3 2007
7,879,608 PUFA polyketide synthase systems and uses thereof 3 2007
7,799,564 PUFA polyketide synthase systems and uses thereof 3 2007
7,718,431 PUFA polyketide synthase systems and uses thereof 3 2007
7,629,450 PUFA polyketide synthase systems and uses thereof 3 2007
7,560,539 PUFA polyketide synthase systems and uses thereof 6 2007
* 2008/0050,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0038,798 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0032,368 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 26 2007
* 2008/0032,369 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
* 2008/0032,367 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 28 2007
8,426,686 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 0 2010
9,382,521 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems 0 2013
 
SEMBIOSYS GENETICS INC. (1)
* 2007/0245,431 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 68 2007
* Cited By Examiner