Transition state structure and inhibitors of thymidine phosphorylases
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United States of America Patent
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Sep 3, 2004
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Sep 5, 2003
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Abstract
The transition state structure of thymidine phosphorylase is provided, along with thymidine phosphorylase inhibitors that resemble the charge and geometry of the thymidine phosphorylase transition state. Also provided are methods of inhibiting a thymidine phosphorylase, methods of treating cancer, and methods of inhibiting angiogenesis which utilize the thymidine phosphorylase transition state inhibitors.
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