Continuous Process for the Assembly of Macromolecular Substances and the Subsequent Capture and Isolation of Mamacromolecular Assembly and a System Suitable for the Process

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United States of America Patent

APP PUB NO 20070276131A1
SERIAL NO

10569372

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Abstract

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The present invention relates to a continuous process and a system for macromolecular assembly and capture (refolding or proteins (e.g. refolding of HAT human .beta.2-microglobulin), hybridization of nucleic acid, nucleic acid analogues, and protein-nucleic acid chimera, aggregation of carbohydrates, and assembly of nanostructures/nanomaterials. The process may comprise the steps of providing fluid compositions comprising at least one of said macromolecular substances in a predominantly unassembled form, providing a dispersion comprising coated, essentially non-porous magnetic particles, combining said fluid compositions and the dispersion of magnetic particles thereby providing a continuous stream, passing said continuous stream through a first mixing device thereby forming magnetic complexes each comprising a magnetic particle and a plurality of macromolecular assembly species; passing the continuous stream through a first capture compartment of a magnetic separator thereby capturing said magnetic complexes; and separating said magnetic complexes from said continuous stream, and isolating said macromolecular assembly species.

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Patent Owner(s)

Patent OwnerAddress
DANMARKS TEKNISKE UNIVERSITETANKER ENGELUNDSVEJ 1 BYGNING 101 A KGS LYNGBY 2800
KOBENHAVNS UNIVERSITETNORREGADE 10 KOBENHAVN K DK-1017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buus, Soren Virum, DK 6 85
Ferre, Henrik Vanlose, DK 3 24
Hansen, Dennis B Rodovre, DK 6 106
Hobley, Timothy J Copenhagen S, DK 3 33
Thomas, Owen RT Binningham, GB 1 13

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