Two-phase mucoadhesive composition
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United States of America Patent
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Issued Date -
Dec 27, 2007
app pub date -
Jan 18, 2007
filing date -
Jun 27, 2006
priority date (Note) -
Abandoned
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Abstract
A novel two-phase, film-forming, mucoadhesive gel composition has been developed. The composition contains an anhydrous non-aqueous solvent, a water-insoluble polymer that is dissolved in the non-aqueous solvent, and a water-soluble polymer that is dispersed in the non-aqueous solvent. The composition adheres to water-bearing surfaces, such as to moistened skin or mucosal surfaces, and can be used to provide extended, local delivery of pharmaceutically active agents from the composition to skin or a mucosal surface. The composition may be solvent-cast to form a mucoadhesive film, which may contain a polymeric backing layer. The mucoadhesive film may further contain a pharmaceutically active agent and may be used to administer the pharmaceutically active agent to skin or mucosal surfaces.
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