Method of Detecting Conformational Change of an Amyloid Protein, a Method of Searching a Substance Having an Activity that Affects to Conformational Change of an Amyloid Protein, and Method of Searching a Therapeutic or Diagnostic Agent for Amyloid-Related Diseases

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United States of America Patent

APP PUB NO 20080003691A1
SERIAL NO

10593880

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Abstract

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The inventors investigated to provide a means for real-time detection and measurement on the process of the amyloid protein aggregation as change(s) in tension and/or elasticity using a force sensor. The present invention provided a method of detecting an amyloidgenic conformational change of a protein using a mechanochemical sensor. The present invention further provided a method of searching a substance having an activity that affects to an amyloidgenic conformational change using said detecting method, as well as a method of searching a therapeutic or diagnostic agent for amyloid-related diseases. The method of the present invention is assumed to contribute to obtain a novel therapeutic or diagnostic agent for amyloid diseases.

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FUENCE CO LTDTOKYO JAPAN TOKYO METROPOLIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kase, Hiroshi Tokyo, JP 77 669
Nonaka, Hiromi Tokyo, JP 24 244
Tachibana, Machiko Niigata, JP 1 1
Tachibana, Masayoshi Niigata, JP 6 65

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