Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use

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United States of America Patent

SERIAL NO

11819514

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Abstract

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The invention provides novel compositions containing at least one phosphodiesterase inhibitor, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing diseases induced by the increased metabolism of cyclic guanosine 3',5'-monophosphate (cGMP).

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Patent Owner(s)

Patent OwnerAddress
NITROMED INC45 HAYDEN AVENUE SUITE 3000 LEXINGTON MASSACHUSETTS 02421 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
de, Tejada Inigo Saenz Madrid, ES 22 300
Earl, Richard A Westford, MA 36 405
Garvey, David S Dover, MA 143 2044
Khanapure, Subhash P Clinton, MA 26 356

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