Methods and compositions for inactivation of dihydrofolate reductase
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United States of America Patent
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Issued Date -
Jan 17, 2008
app pub date -
May 17, 2007
filing date -
May 19, 2006
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are methods and compositions for inactivating dihydrofolate reductase genes, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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