Method and apparatus for 3-D imaging of internal light sources
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United States of America Patent
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Oct 13, 2009
Grant Date -
Jan 24, 2008
app pub date -
Jul 29, 2007
filing date -
Jul 16, 2002
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Abstract
The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
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