Semi-synthetic conversion of paclitaxel to docetaxel
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United States of America Patent
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Mar 15, 2011
Grant Date -
Feb 28, 2008
app pub date -
Jun 29, 2005
filing date -
Jun 29, 2004
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Abstract
A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2′, C-7 and C-10 positions and introducing a t-Boc group at the nitrogen of the amide group at the C-3′ position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
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