Pharmaceutical compositions of semicarbazones and/or thiosemicarbazones and/or their derivatives and products of these compositions and their uses as anticonvulsant, anti-nociceptive and anti-inflammatory agents, and in the angiogenic therapy
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United States of America Patent
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app pub date -
Jul 30, 2007
filing date -
Feb 6, 2002
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Abstract
The present invention is characterized by obtaining inclusion compounds of semicarbazones and/or thiosemicarbazones and/or their derivatives in cyclodextrins and/or their derivatives, which once tested in experimental models of epilepsia allowed the reduction of anticonvulsant dose from 100 mg/kg to 25 mg/kg. This means an increase in bioavailability of compounds in biological systems. Hence inclusion compounds between semicarbazones and/or thiosemicarbazones and cyclodextrins and their derivatives could be new candidates as anticonvulsant agents. The present invention is also characterized by the increase in the anticonvulsant efficacy of the inclusion compounds between cyclodextrins and/or their derivatives and semicarbazones and/or thiosemicarbazones and/or their derivatives in comparison to free components.
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