Peptidic And Peptidoid Bradykinin B1 Receptor Antagonists And Uses Thereof
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United States of America Patent
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Issued Date -
Mar 13, 2008
app pub date -
Aug 19, 2005
filing date -
Aug 19, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides for new peptidic and peptidoid Bradykinin B.sub.1 receptor antagonists of formula (1) having good to excellent affinities and selectivity for the BKB.sub.1 receptor, and increased resistance to enzymatic degradation, superior pharmacokinetic properties, both in vitro and in vivo, with capability to significantly prevent and treat conditions wherein BKB.sub.1Rs are induced and over-expressed.
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