Drug Delivery Systems Comprising Solid Solutions of Weakly Basic Drugs
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United States of America Patent
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Issued Date -
Mar 20, 2008
app pub date -
Aug 29, 2007
filing date -
Aug 31, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 .mu.g/mL at pH 6.8.
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