2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases

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United States of America Patent

SERIAL NO

11814239

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Abstract

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Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. The compounds for use in the compositions and methods provided herein have formulae (I) Protein tyrosine phosaphatase, including PTB-IB, mediated diseases and disorders include diabetes including Type 1 and Type 2 diabetes (and associated complications such as hypertension, ischemic diseases of the large and small blood vessels, blindness, circulatory problems, kidney failure and atherosclerosis), syndrome X, metabolic syndrome, glucose intolerance, insulin resistance, obesity, cancer, and neurodegenerative diseases.

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Patent Owner(s)

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METABASIS THERAPEUTICS INC3911 SORRENTO VALLEY BLVD SUITE 110 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheruvallath, Zacharia S San Diego, CA 19 135
Rajappan, Vasanthakumar San Diego, CA 2 5
Rideout, Darryl San Diego, CA 20 124
Semple, Joseph San Diego, CA 1 1
Shenderovich, Mark San Diego, CA 7 53
Thoresen, Lars San Diego, CA 22 158
Tsai, Chung-Ying San Diego, CA 6 15
Wu, Feiyue Poway, CA 6 22
Yalamoori, Venkatachalapathi San Diego, CA 9 261

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