Modified Vaccinia Ankara virus variant
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United States of America Patent
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Dec 2, 2008
Grant Date -
Apr 17, 2008
app pub date -
Dec 4, 2007
filing date -
Nov 23, 2000
priority date (Note) -
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Abstract
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost inoculation regimen.
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