LIPOSOME DRUG CARRIERS WITH PH-SENSITIVITY
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United States of America Patent
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Issued Date -
Apr 17, 2008
app pub date -
Jun 13, 2007
filing date -
Jun 13, 2006
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Abandoned
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Abstract
A liposome composition for delivering of a biologically active agent having at a least first rigid lipid and a second rigid lipid each having a head group and a hydrophobic tail; a polyethyleneglycol-linked lipid having a side chain matching at least a portion of the first or the second lipid; and an entrapped biologically active agent. The first lipid can be a zwitterionic lipid and the second lipid can have a titratable head group. The composition can be adapted to release the entrapped at a certain pH.
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