HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS

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United States of America Patent

APP PUB NO 20080090847A1
SERIAL NO

11951214

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

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Patent Owner(s)

Patent OwnerAddress
PLIVA D DZAGREB CITY OF CROATIA ZAGREB GRAD ZAGREB

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ala, Paul J Newark, DE 6 9
Ali, Janid A Waltham, MA 6 7
Clement, Jacob J Vancouver, CA 4 9
Connelly, Patrick R Harvard, MA 78 6230
Faerman, Carlos H Acton, MA 9 28
Faraday, Christopher San Francisco, CA 2 6
Gazzaniga, John V Worcester, MA 3 7
Magee, Andrew S Maynard, MA 7 61
Marchese, Salvatore A Malden, MA 3 7
Moe, Scott T Marlborough, MA 37 816
Navia, Manuel A Lexington, MA 32 312
Perola, Emanuele Cambridge, MA 59 854
Will, Paul Stoneham, MA 10 33

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