Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
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United States of America Patent
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Issued Date -
May 8, 2008
app pub date -
Sep 27, 2007
filing date -
Sep 28, 2006
priority date (Note) -
Abandoned
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Abstract
One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
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