Polypeptides for Modulating Binding of Trp Channel Proteins and Trp-Associated Proteins
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United States of America Patent
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Issued Date -
May 22, 2008
app pub date -
Dec 22, 2004
filing date -
Dec 23, 2003
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Abstract
This invention relates to inhibitors and modulators of the binding between a transcient receptor potential (TRP) channel protein and a TRP-associated binding protein. In particular inhibitors and modulators of the binding between the TRPM7 channel protein and PDZ-domain containing TRP-associated proteins. These modulators and inhibitors are used to control Ca2+ transport through TRPM7 channel proteins and reduce damage to mammalian cells, including brain and spinal cord cells, after ischemia or traumatic injury.
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