CONTROLLED SURFACE TOPOGRAPHY FOR ENHANCED PROTEIN CRYSTALLIZATION RATES
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United States of America Patent
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Issued Date -
May 22, 2008
app pub date -
Nov 20, 2007
filing date -
Nov 21, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A method for accelerating protein crystallization on a substrate is provided, including the steps of providing a coating layer comprising a colloidal solution containing inert particles on at least one discrete testing portion of a testing substrate to provide at least one coated portion, and drying the coated portion so that the coated portion has an enhanced surface topography defined by the characteristics of the coating layer. A supersaturated protein solution is applied to the coated portion, and the testing substrate is placed in an incubator for crystallization, and the growth rate of the protein crystals is accelerated during incubation due to the enhanced surface topography of the at least one coated portion. The testing substrate is evaluated to determine the degree of protein crystallization until crystallization in complete, and the protein crystals are subsequently removed from the testing substrate subjected to specific characterization testing.
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